International Experts Summit on Oncology & Cancer Care (Oncology Summit-2027)

  Cancer Cell Extracellular Vesicle Communication: How Tumors Send Molecular Signals to Shape Their Microenvironment Introduction Cancer is more than a collection of abnormal cells growing uncontrollably. Tumors develop within a complex biological environment where cancer cells communicate with immune cells, fibroblasts, blood vessel cells, and other surrounding tissues. These interactions can influence tumor growth, immune responses, metastasis, and treatment outcomes. One important mechanism of this communication is the release of extracellular vesicles (EVs)—small, membrane-enclosed particles that carry biological molecules from one cell to another. Extracellular vesicles can transport proteins, lipids, and different types of nucleic acids. After reaching recipient cells, their cargo may influence cellular signaling, gene expression, metabolism, and immune activity. Research increasingly suggests that EV-mediated communication contributes to interactions between tumors a...

  Biomolecular Condensates in Cancer: How Phase Separation Shapes Tumor Biology and Therapy Resistance Introduction Cancer biology has traditionally been understood through genetic mutations, abnormal signaling pathways, altered metabolism, immune interactions, and changes in the tumor microenvironment. However, an additional layer of cellular organization is attracting increasing attention: biomolecular condensates . Inside cells, many proteins and RNA molecules do not simply remain uniformly distributed. Instead, they can gather into dynamic, membrane-free compartments that concentrate selected molecules and organize biochemical reactions. These structures are broadly known as biomolecular condensates . One mechanism that can contribute to condensate formation is liquid-liquid phase separation (LLPS) . Through this process, proteins, RNA, DNA-associated factors, and other biomolecules can separate into concentrated and less-concentrated phases under appropriate physical a...

  Cancer Proteoforms: Decoding Protein Diversity for Next-Generation Precision Oncology Introduction Modern cancer research has increasingly moved beyond the question of which genes are altered in a tumor to a broader question: How do those genetic and regulatory changes ultimately affect the proteins that drive cancer biology? Genomic sequencing has transformed oncology by identifying mutations, copy-number changes, and other alterations that can influence cancer development and treatment response. Transcriptomics has added information about RNA expression and alternative transcripts. However, proteins are the molecules that perform many of the functions responsible for cellular behavior, including signaling, metabolism, structural organization, immune interactions, and response to therapy. A single gene does not necessarily produce only one molecularly identical protein. Genetic variation, alternative RNA processing, and post-translational modifications can generate diffe...