Epitranscriptomics in Cancer: How RNA Modifications Are Shaping Precision Oncology
Epitranscriptomics in Cancer: How RNA Modifications Are Shaping Precision Oncology Introduction Cancer biology is increasingly understood as a complex network of genetic, epigenetic, transcriptional, and post-transcriptional processes. While genomics has transformed the understanding of mutations and alterations that drive cancer, researchers are now focusing on another important layer of biological regulation: the chemical modification of RNA molecules . This emerging field is known as epitranscriptomics . RNA was traditionally viewed primarily as an intermediate molecule that carries genetic information from DNA to proteins. Modern RNA biology has demonstrated that RNA molecules are extensively modified after transcription and that these modifications can influence RNA stability, processing, localization, translation, degradation, and interactions with regulatory proteins. More than 170 RNA modifications have been identified across different RNA species, creating a comp...